Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 121 Reviews
8
Supplement Facts
Serving Size:   1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%

Top Medical Research Studies

9
Vitamin D3 correction improves pain
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
Effectiveness of calcitriol combination therapy
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.

Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.

Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
Vitamin D reduces fracture risk
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.

Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.

In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More

Most Useful Reviews

9
Eases bone pain
566 people found this helpful
An ideal solution for those struggling to swallow large capsules. After recovering from COVID, I experienced significant bone pain, but after taking Vitamin D3 for a week, the pain improved. Now my family joins me in taking it.
Read More
7.5
Reduces bone pain
537 people found this helpful
I experienced decreased drowsiness and chronic fatigue during winter after taking Vitamin D. My chronic pain in injured joints improved, as did my mood and overall energy levels.
Read More
9
Quick bone pain relief
525 people found this helpful
The taste is absent, and I regularly order this product. My health strengthened rapidly, and I believe it significantly helped with bone pain due to its balanced dosage, which caters well to most people.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
  • All Researches
9
Vitamin D3 correction improves pain
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
Effectiveness of calcitriol combination therapy
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.

Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.

Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
Vitamin D reduces fracture risk
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.

Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.

In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More

User Reviews

USERS' SCORE
Good
Based on 121 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Eases bone pain
566 people found this helpful
An ideal solution for those struggling to swallow large capsules. After recovering from COVID, I experienced significant bone pain, but after taking Vitamin D3 for a week, the pain improved. Now my family joins me in taking it.
Read More
7.5
Reduces bone pain
537 people found this helpful
I experienced decreased drowsiness and chronic fatigue during winter after taking Vitamin D. My chronic pain in injured joints improved, as did my mood and overall energy levels.
Read More
9
Quick bone pain relief
525 people found this helpful
The taste is absent, and I regularly order this product. My health strengthened rapidly, and I believe it significantly helped with bone pain due to its balanced dosage, which caters well to most people.
Read More
9
Less bone pain
211 people found this helpful
The quality is impressive, with carefully selected ingredients. My bone pain has ceased, and I noticed visible results in a week.
Read More
9
Improved bone strength
209 people found this helpful
Vitamin D3 is crucial for calcium absorption. Deficiency leads to weak bones and bone pain, so greater intake is beneficial for peak bone density.
Read More

Frequently Asked Questions

9
Less bone pain
211 people found this helpful
The quality is impressive, with carefully selected ingredients. My bone pain has ceased, and I noticed visible results in a week.
9
Relieved bone pain
6 people found this helpful
After pregnancy, I had low levels of vitamin D3. Thanks to these vitamins at a dose of 5000 IU, my level rose from 10 to 39 after two months. I immediately felt better and my bone pain in the lower back stopped. I definitely recommend this product!
9
Improved overall vitality
21 people found this helpful
Excellent supplement! I chose the right dosage and didn't exceed it. It has helped strengthen my bones, improved my immunity, and reduced bone pain significantly. After three weeks, I feel more active and my mood has improved.
9
Eases bone pain
566 people found this helpful
An ideal solution for those struggling to swallow large capsules. After recovering from COVID, I experienced significant bone pain, but after taking Vitamin D3 for a week, the pain improved. Now my family joins me in taking it.
7.5
Reduces bone pain
537 people found this helpful
I experienced decreased drowsiness and chronic fatigue during winter after taking Vitamin D. My chronic pain in injured joints improved, as did my mood and overall energy levels.
9
Teeth strong
106 people found this helpful
Taking D3 has significantly improved my post-pregnancy bone health. I combine it with calcium, and there's a noticeable reduction in bone pain and stronger enamel, which has been reassuring.
9
Improved bone health
10 people found this helpful
If you wish to enhance your life and health, take vitamin D3. It’s the number one vitamin. Everyone should include Vitamin D3 in their first aid kit, taking between 5,000 and 10,000 IU along with vitamin K2 for better absorption. This is vital for bone pain and immunity. The ingredients are natural, the quality is excellent, and the size is small. Our sun exposure is limited, but this vitamin yields excellent results.
9
Significant pain reduction
26 people found this helpful
I received my order on time. The vitamin D3, K2, magnesium, and zinc combination improved my bone pain. As a type 2 diabetes patient, I advise this formula; it’s been effective for my health.
8
Immunity supported
109 people found this helpful
This vitamin is great for both immune and bone health. I've been taking it regularly along with omega, and it's making a positive difference in how I feel.
9
Improved immunity
18 people found this helpful
This excellent product is taken once daily after a fatty meal for better absorption. For those with poor immunity or bone pain, I recommend daily vitamin D with omega-3 for three months. It significantly aids those with skin, hair, or bone problems.
8
Vitamin D reduces fracture risk
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.

Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.

In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
9
Vitamin D3 correction improves pain
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.

By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.

Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
Effectiveness of calcitriol combination therapy
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.

Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.

Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.

References

  1. Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
  2. Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
  3. Han K, Wang X. Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study. Medicine (Baltimore). 2024;103:e40171. doi:10.1097/MD.0000000000040171
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